Myo-inositol + melatonin is part of the “poor responder” protocol at CCRM. 
Gynecol Endocrinol. 2011 Nov;27(11):857-61. Epub 2011 Apr 5.

Unfer VRaffone ERizzo PBuffo S.


AGUNCO Obstetrics and Gynecology Centre, via G. Cassiani, Rome, 15-00155, Italy.



Several factors can affect oocyte quality and therefore pregnancy outcome in assisted reproductive technology (ART) cycles. Recently, a number of studies have shown that the presence of several compounds in the follicular fluid positively correlates with oocyte quality and maturation (i.e., myo-inositol and melatonin).


In the present study, we aim to evaluate the pregnancy outcomes after the administration of myo-inositol combined with melatonin in women who failed to conceive in previous in vitro fertilization (IVF) cycles due to poor oocyte quality.


Forty-six women were treated with 4 g/day myo-inositol and 3 mg/day melatonin (inofolic® and inofolic® Plus, Lo.Lipharma, Rome) for 3 months and then underwent a new IVF cycle.


After treatment, the number of mature oocytes, the fertilization rate, the number of both, total and top-quality embryos transferred were statistically higher compared to the previous IVF cycle, while there was no difference in the number of retrieved oocyte. After treatment, a total of 13 pregnancies occurred, 9 of them were confirmed echographically; four evolved in spontaneous abortion.


The treatment with myo-inositol and melatonin improves ovarian stimulation protocols and pregnancy outcomes in infertile women with poor oocyte quality.

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  1. mira

     /  February 6, 2015

    Hi …Thanks for this beautiful blog.i am 37 and only problem is amh is 0.2 but no issue with pcos.less ovarian reserve.1 failed iui.i need help from u to understand if I hv to take anything else apart from these supplements. 1.Fish oil tablets 2.vit b tablets 3.coq10 4. Myo-inositol 4000 mg per day in powder form 5.dha 6.aspirin 7. Folic acid .will be grateful for your time.hope by 2015 Dec I can share good news with you.

  1. Supplementality and Body Revolution « the unexpected trip

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